One of the most important problems to be faced when considering the application of a nanodevice in medicine regards its potential toxicity and biocompatibility with living cells and tissues. We thus aim to study the toxicological aspect of our TNH in order to obtain a safe nanosystem, when in contact with living cells and biological fluids. In addition we want also to program the biodegradation process of the TNH, resulting into safe by-products and correct biodegradation timing at the end of its working function.
–> BIODEGRADATION STUDY OF THE TNH: Forecasting the biostability/biodegradation behavior of a nanomaterial, and in particular of our TNH in the biological context, is a fine interplay between the chemical and structural features with the biological environment. Therefore, we are carrying on an accurate and systematic evaluation of role played by the size, morphology and the presence of functional groups of the TNH, and the biological conditions (time, temperature, pH, type of media…)
–> SAFETY ASSESSMENT OF THE TNH: the key challenge of this task is to understand how the TNH and its by-products behave in biological fluids. The final aim is to obtain a nanomaterials which is safe-by-design, thus acting back on the preparation process and carefully evaluating the cell viability of tumor and healthy cells.