Cancer Associated E17K Mutation Causes Rapid Conformational Drift in AKT1 Pleckstrin Homology (PH) Domain.

TitleCancer Associated E17K Mutation Causes Rapid Conformational Drift in AKT1 Pleckstrin Homology (PH) Domain.
Publication TypeJournal Article
Year of Publication2013
AuthorsKumar A, Purohit R
JournalPloS one
Volume8
Issue5
Paginatione64364
Date Published2013
ISSN1932-6203
Abstract

AKT1 (v-akt murine thymoma viral oncogene homologue 1) kinase is one of the most frequently activated proliferated and survival pathway of cancer. Recently it has been shown that E17K mutation in the Pleckstrin Homology (PH) domain of AKT1 protein leads to cancer by amplifying the phosphorylation and membrane localization of protein. The mutant has shown resistance to AKT1/2 inhibitor VIII drug molecule. In this study we have demonstrated the detailed structural and molecular consequences associated with the activity regulation of mutant protein.

DOI10.1371/journal.pone.0064364
Alternate JournalPLoS ONE